| Pair Name | Butein, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Butein (PubChem CID: 5281222 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Butein, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2B33.4] | Leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Expression | TNFRSF10A | hsa8797 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | U-937 | Adult acute monocytic leukemia | Homo sapiens (Human) | CVCL_0007 |
| Result | Our data suggests that combined treatment with butein and TRAIL may provide a safe and effective strategy for treating cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Arch Pharm Res. 2008 Sep;31(9):1179-86. doi: 10.1007/s12272-001-1286-2. | Click |
